Isikli ranks 153rd by electorate among the 184 localities of Adıyaman. The neighborhood has a single ballot box, and 82 voters were registered there for the 2023 parliamentary election.
63 people voted at that election. AK Parti took the most votes with 32; Yeşil Sol Parti followed with 20. AK Parti's share here is 10.8 points above the district average. In the presidential runoff, 36 of 58 valid votes went to Recep Tayyip Erdoğan — essentially the district average. At the 2017 referendum 54 of 63 valid votes were 'yes' — 21.9 points above the district average.
At the 2024 local election the neighborhood went to AK Parti with 27 votes, while Adıyaman as a whole was won by CHP. The neighborhood has stayed on the same line since 2014: AK Parti has finished first in all of the last 7 elections. The tightest race came at the 2015 parliamentary election: AK Parti took 39 votes to Yeşil Sol Parti's 27 — a margin of just 12 votes. Turnout at the 2024 local election was 64.1%, 8.2 points below the district average.