Karlisu-Karaksi is one of the localities of Hatay Merkez; it had 2,574 registered voters at the 2011 parliamentary election.
The neighborhood parts ways with the district as a whole. At the 2011 parliamentary election it went to AK Parti with 59.8%, while across Hatay Merkez the leading party was CHP, with AK Parti here running 33.3 points above its district average. At the 2010 referendum 64.6% of the neighborhood voted 'yes' — 36.4 points above the district average.
Turnout at the 2009 local election was 94.4%, 9.1 points above the district average. The tightest race came at the 2009 local election: AK Parti took 496 votes to CHP's 487 — a margin of just 9 votes. At the 2009 local election the neighborhood went to AK Parti with 40.9%, while Hatay Merkez as a whole was won by CHP. First place has changed hands 3 times here since 2009.