Karadere-Harmancik is one of the localities of Kahramanmaras Merkez; it had 540 registered voters at the 2011 parliamentary election.
AK Parti took 87.4% in the neighborhood at that election. Across Kahramanmaras Merkez the same party stood at 80.3%, putting the neighborhood 7.2 points above the district average. At the 2010 referendum 92.4% of the neighborhood voted 'yes'; across the district that was 89.4%.
At the 2009 local election the neighborhood went to MHP with 46.6%, while Kahramanmaras Merkez as a whole was won by AK Parti.